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Topiramate
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Topiramate

Topiramate is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Synthesis of enzymes of the lactose operon during diauxic growth of Escherichia coli. The mice were then exposed nose-only to the PM2.5 fraction of SRM2975 DEP or air alone for 5 h beginning 1 h after OVA challenge. Development of a serum free, feeder-free (SFFF) culture platform for human embryonic stem cells (hESC) will be important for the expansion of hESC for future cell therapy applications. Sucrose gradient profiles of the modified nucleoprotein complexes further confirm that the digestion profile for micrococcal nuclease is altered by cis-DDP binding and that the greatest changes occur at the initial stages of digestion. Expression of the P and F adhesins individually or concurrently was associated with the presence of a single copy of pap-related sequences.

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To investigate the epidemiological features of back pain, spondyloarthritis (SpA) and ankylosing spondylitis (AS) in Beijing Shougang district. To determine the patterns of MTX use in patients with CD by Canadian gastroenterologists, examining the reasons for choosing MTX versus AZA/6-MP, the doses and routes of administration of MTX, and how patients on MTX are monitored, including the use of liver biopsy. To compare mean lung density (MLD) of paired inspiratory and expiratory thin-section CT scans acquired after patient instruction or using spirometric gating. However, it is known that fatty acids also influence a number of other relevant mechanisms involved in atherosclerosis such as lipid peroxidation, inflammation and haemostasis. Some of the artistic representations of surface anatomy depict other motives, as is the case of the self-portrait of Michelangelo, painted in the Sistine Chapel, in honour of St.

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In binge eating prone (BEP) rats, we found novel object recognition (NOR) as well as Barnes maze reversal learning (BM-RL) deficits. Specimens were collected after completion of first-line chemotherapy in patients who had responding or stable disease and 3, 6, and 12 months after initiation of marimastat (10 mg orally twice daily) or placebo. The empirical ethnographical data base of nicotine application is compared to the comprehensive literature of experimental clinical studies of tobacco and nicotine. The effect of anthropogenic impoundment on dissolved organic matter characteristics and copper binding affinity: Insights from fluorescence spectroscopy. PET has been shown to be helpful in staging, especially in evaluating for distant metastases.

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Distal defect of the humerus, a possible normal variant: a case report. In 17 patients 36 fluorescence-guided biopsies were taken from fluorescing and non-fluorescing tissues for further evaluation. Several developments have also revolved around possible exploitation of the filaments alone without their motor partners.

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This is illustrated by intraoperative pictures which may assist others who find themselves faced with this injury. Here, we show evidence that, regardless of the strategy used, the neural network involved in outright stopping is ubiquitous. The recognition that MMPs facilitate tumor cell growth, invasion and metastasis of cancer has led to the development of MMP inhibitors as cancer therapeutic agents. The patient underwent the operation for acromioclavicular luxation 2 years ago--osteosynthesis with the use of 2 Kirschner wires.

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Food consumption was evaluated with a validated food-frequency questionnaire, and adherence to the Mediterranean diet was assessed on the basis of a diet score that incorporated the inherent characteristics of this diet. Endovascular treatment of thoracic aortic pathology has emerged as a viable alternative to open surgical repair in both the elective and emergent settings. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules.

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Evolution of Public Health Emergency Management From Preparedness to Response and Recovery: Introduction and Contents of the Volume. Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers. This shows that Lactobacillus plantarum WCFS1 is unable to respond to this growth rate reduction, most likely because the growth-related transcripts and proteins are diluted by the enormous amount of gratuitous folate-related transcripts and proteins.

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By 9 months, only one specimen had polymeric material left in the screw track. The use of extracorporeal shock wave lithotripsy in patients with aortic aneurysms. Oxidized low-density lipoprotein (ox-LDL) promotes cardiac differentiation of bone marrow mesenchymal stem cells via activating ERK1/2 signaling. Statins are first-line therapy for reducing high cholesterol levels. The progression of pulmonary edema and alveolar flooding was assessed by monitoring the leakage of fluorescein-labeled albumin and rhodamine dye from the pulmonary capillaries into the alveoli.

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ABI stimulation was applied at seven different sites using either wide bipolar stimulation across the array or in subsections of the array from medial to lateral and inferior to superior. DTI and fiber tractography were used to reconstruct the corticospinal tracts and the medial lemnisci. In the present study, we demonstrated up-regulation of FKBP3 expression, both at mRNA and protein levels, in NSCLC samples which closely correlated with poor survival in NSCLC patients.

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Evidence that the effect of beta-adrenergic blockade on the haemodynamic response of hypertensive patients to exercise is not solely rate-dependent. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration.

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The anti-inflammatory activity was determined by carrageenan-induced rat paw edema and cotton pellet-induced granulation method while the immunomodulatory activity was estimated by phagocytic assay method, hemagglutinating antibody (HA) titer assay, delayed-type hypersensitivity assay method, plaque forming cell assay and determination of immunoprophylatic activity. He concludes that qualitative research complements quantitative research and that a subjective element exists in both: numbers are also words because behind numbers there is a reflexive process and a human interpretation. Forty C57BL/6J mice were inoculated with LLC cells suspension (1 x 10(7) cells/ mL) in right armpit subcutaneously. The general pattern of over-involvement for younger drivers pervades virtually every combination of factors examined.

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Nosocomial spondylodiscitis after intradiscal electrothermal therapy: Case series. This process of emmetropisation appears to have been impeded by the consistent wearing of hypermetropic spectacle correction from the age of 6 months. A moving blocker-based strategy was previously proposed to simultaneously estimate scatter and reconstruct the complete volume within the field of view (FOV) from a single CBCT scan.

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Importantly, blockade of GSK-3beta inhibition abrogated IGF-I- but not LiCl-dependent stimulation of myogenic mRNA accumulation, suggesting that the promyogenic effects of IGF-I require GSK-3beta inactivation and revealing an important negative regulatory role for GSK-3beta in myogenesis. Assessment of epoxidized soy bean oil (ESBO) migrating into foods: comparison with ESBO-like epoxy fatty acids in our normal diet.

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It is known that extracellular matrix-degrading enzymes play an important role in tissue remodeling and that large amounts of structural proteins including types I, III, IV, and V collagens and elastin are produced by smooth muscle cells (SMC) in the arterial wall. This study describes a CheR function that opposes the signaling consequences of its catalytic activity. An optimized method for routine HLA-B27 screening using flow cytometry. Radiation sensitivity of the RNA-containing phage MS2 during its intracellular growth

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rHuEPO treatment (150 IU/kg/d 3 times a week) is effective and safe in children with chemotherapy-induced anemia. Geminivirus replication origins have a group-specific organization of iterative elements: a model for replication. ODD onset, in contrast, is unrelated to trauma exposure but is associated with elevated risk of experiencing trauma later in development. Further, AURKA inhibition stimulates error-prone NHEJ repair of DNA double-strand breaks with incompatible ends.

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The equivocal metabolic response to endotoxaemia in type 2 diabetic and obese ZDF rats. Therefore, substituting group testing in place of one-on-one interviews may broaden the utility of the scale.

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Dilatation of the ductus arteriosus by diazoxide in fetal and neonatal rats. We also present an efficient algorithm for solving the associated large-scale systems.

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Validation of Next-Generation Sequencer for 24-Chromosome Aneuploidy Screening in Human Embryos. Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. The aim of the study was to reveal barriers to providing dental care for residents in long-term care (LTC) facilities.

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On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. Propagation of these bees from 1 yr to the next has been seriously hampered by chalkbrood, a larval disease caused by the fungus Ascosphaera aggregata Skou. We report a case of leprosy observed in a French woman who had lived in Africa 30 years earlier. Arterial ketone body ratio (AKBR), which indicates the mitochondrial energy charge level, decreased with the development of hypoxia, and in the hypoxia-halothane group, the decrease of AKBR was significantly greater than in the hypoxia-thiamylal group at FIO2 0.08. This paper provides a detailed phenotypic analysis of the abscisic acid (ABA) hypersensitive Cap Binding Protein 20 (cbp20) mutant.

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During endoscopy, esophageal biopsies were collected from case and controls. The advent of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV. Various methods are available to manage the hematopoietic toxicity. The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. delusions, disorganized speech, disorganized or catatonic behavior or negative symptoms).

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Physical mapping of repetitive DNA families in the karyotypes of fish is important to understand the organization and evolution of different orders, families, genera, or species. LC(E)-BoTIM(A) inhibited release of calcitonin gene-related peptide from sensory neurons mediated by transient receptor potential vanilloid type 1 and attenuated capsaicin-evoked nociceptive behavior in rats, following intraplantar injection. Is the decrease in LVEDV the mechanism of action of continuous positive airway pressure in diastolic heart failure? Five strains hybridized to a toluene ortho-hydroxylase catabolic probe, and two of those also hybridized to a toluene meta-hydroxylase probe.

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Data were collected from three 8- to 10-week, randomized, placebo-controlled, double-blind trials of paroxetine in pediatric patients with major depressive disorder or obsessive-compulsive disorder. Currently, nothing is known on the evolution of the morphology of the ligand shell during the reaction.

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5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. The right-sided approach for repair of infracardiac TAPVC contributes to produce favorable outcomes.

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Furthermore, aggressive behavior, verbally disruptive/attention-seeking behavior, hallucinatory symptoms and wandering behavior were more common with concurrent dysphoria regardless of cognitive function. Cervical screening in Denmark - a success followed by stagnation. Sixteen patients with APL who were treated with ATRA or As2O3 alone and achieved complete remission (CR) were analyzed. Regulation of prolactin gene expression by vasoactive intestinal peptide and dopamine in the turkey: role of Ca signalling. The more general irresponsibility and disregard for the rights of others characteristic of APD is equally evident in both antisocial groups.

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Attenuated VPP was found to correlate with subsequent P3 amplitude reduction and to predict accuracy when performing a facial emotion discrimination task. Studies were identified using MedLine, EconLit and HEED and were evaluated based on their SEP specific inputs and methods of quantification of the health and financial inequalities. The patients who had quadriceps turndown and the tibial tubercle osteotomy had equivalent scores postoperatively both of which were significantly lower than the standard group. The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model.

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Effect of season and dietary energy concentration on composition and strength of skin in naked neck fowl. According to a clinic case, the authors pointed out the role of histological diagnosis in the therapeutic approach of large intestinal adenomas. Atomic transition probabilities and tests of the spectroscopic coupling scheme for N I. Based on sequence alignment and further biochemical analysis, the amino acid residue substitutions that conferred increased TAG accumulation were shown to be present in the DGAT1-PTMD9 region of other higher plant species.

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Two modern methods of reirradiation, intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), are established for patients with recurrent or second primary squamous cell carcinoma of the head and neck (rSCCHN). Findings from the individual testing in Stage 1 resulted in significant changes to documentation and training materials and identification of bugs to be corrected.

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The maternal and developmental toxicity of combined exposure to restraint stress and caffeine was assessed in mice. In this study, PCR-RFLP of a number of ILTV genes/genomic regions including gE, gG, TK, ICP4, ICP18.5, and open reading frame (ORF) B-TK was used to examine a number of historical and contemporary Australian ILTV isolates and vaccine strains. Using a metric to measure island biodiversity loss, we estimate it will take at least eight million years to regain pre-human diversity levels. Verticillium dahliae can trigger plant cells to die through induction of a PCD mechanism involved in pathogenesis. Comparison of hydroxyzine-meperidine and promethazine-meperidine for analgesia during labor.

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These results highlight the complexity of modulating cell death and therapeutic strategies that may need to consider different consequences on cell death dependent on the model. Identical products were formed when the reaction was conducted under argon. While the general theory of measuring organ perfusion using exogenously administered freely diffusible tracers was originally formulated over 40 years ago, the application of NMR techniques for tracer detection is a recent development.

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We examined several parameters to determine which variables influence the success of Dx/HA injection, including preoperative reflux grade, bladder diverticula, neurogenic bladder, ureteral duplication, perioperative urinary tract infection, dysfunctional voiding, laterality of reflux and amount of Dx/HA injected. The authors recommend that examination of the eyes be included in the autopsies of all small children who died without an obvious cause of death. Use of CD-ROM-based tool for analyzing contouring variations in involved-field radiotherapy for Stage III NSCLC.

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Hypothalamic blood flow following goldthioglucose-induced lesions. The derivative values of stability index defined in the phase space approximately 200 ms before muscle inactivation were also larger than those before activation for some muscles.

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Stratified analysis of DMPA use investigated the determinants of BMD in both groups. We report the door-to-balloon times for the pre- and postpilot patients in the index hospital and describe the details of the current Level 1 MI Program. The rate variations along the years of study suggest a cyclic change, with a hemicycle of six years. The 3LGM(2) tool has been used to build a model of the health information system of the German federal state Saxony. Surface-assisted cyclodehydrogenation provides a synthetic route towards easily processable and chemically tailored nanographenes.

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This facilitates quick and each access to multiple selected sources of specific guidance. Ceftriaxone-associated cholelithiasis: 30 min drip infusion versus bolus injection. Lineage specific expansions (LSEs) have given rise to abundant gene families in Plasmodium.

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The proposed NHS DPP: an intensive lifestyle intervention focusing on dietary advice, physical activity and weight loss. Effect of the cavity varnish on the retention and pulp irritation of restorations. For accurate positioning of the prostate in external radiotherapy, transabdominal ultrasound localization and positioning systems are available.

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No cross-contamination between fractions with different numbers of double bonds was detected with the HPLC method, was demonstrated by subsequent gas chromatographic analysis of the fatty acid moieties, following transmethylation. Endoscopic visibility during index endoscopy and mean duration of procedure. Cecal organic acids were positively and pH was negatively correlated with the absorption of these minerals, although the effects varied.

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Most of these dissertations have dealt with the treatment of acute ruptures versus the more technically challenging, neglected, ancient rupture. The success of ensemble docking often requires the careful selection of complementary protein conformations, through docking and scoring of known co-crystallized ligands. We found that pharmacological inhibition of glycolysis and, thus, activation of AMPK, in the VMH attenuates the anorectic effect of the GLP-1R agonist exendin-4 (Ex4), indicating that glucose metabolism and inhibition of AMPK are both required for this effect. Taken together, these findings demonstrate that Ab1-induced ectodomain oligomerization arrests endothelial-cell growth through catalytic panamor medication administration activity of the CD148 cytoplasmic domain.

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HFE mRNA and HFE protein were increased and Nramp2 mRNA was decreased by increasing cellular iron status in Caco-2 cells. We previously demonstrated beneficial effects of physical volfenac gel buying activity on cardiovascular disease (CVD) risk factors, body mass index (BMI) and fat mass in pre-pubescent obese children. PCR-SSO (sequence-specific oligonucleotide) and PCR-SSP (sequence-specific primers) methods are most frequently used for routine typing of HLA class I alleles. Variation of bar-press duration: where do new responses come from?

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Primary epiploic appendicitis is a rare but well known intraabdominal inflammatory process that characteristically presents with an onset of symptoms similar to diverticulitis, appendicitis and other abdominopelvic processes. Consecutive stages of ovaries undergoing oogenesis over a 4-month time course were examined morphologically and assessed with respect to content of sperm receptor mRNA, as well as the content and subcellular distribution of the sperm receptor glycoprotein. Using an attentional-capture paradigm, we normozide information varied systematically (a) the number of possible target colors from 1 to 4 and (b) the presence or absence of a colored ring surrounding the nontarget item displayed 200 ms before the target.

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Significant difference in CCT values between the high-resolution Pentacam imaging system and the ultrasound pachymeter suggests that the 2 techniques cannot be used interchangeably in clinical practice. Application of space syntax theory in the study of medical-surgical nursing units in urban hospitals. SDS-polyacrylamide gel electrophoresis and western blot results demonstrated that the CgCaspase-1 zymogen could atorvastatin price meijer cakes be cleaved into p20p10, p20 and p10 in prokaryotic expression systems, and the C-terminus of CgCaspase-1 was also cleaved into p20 and p10.

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