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Armodafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Armodafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore does not get enough restful sleep). Armodafinil is in a class of medications called wakefulness-promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

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In view of the data currently available, FDG PET seems to be a clinically useful predictor of viable tumour in post-chemotherapy residuals of pure seminoma. 3D domain-swapped human cystatin C with amyloidlike intermolecular beta-sheets. In a prospective study of 50 epileptic patients (20 with a left hemisphere epileptic focus, 20 with a right one and 10 with a cryptogenic generalized epilepsy), the authors show that depression as appreciated by the H.A.R.D. While ICC is generally associated with a poor prognosis, some patients will be LT. Cardio-renal syndrome (CRS) is a renal dysfunction occurring in a large percentage of patients hospitalized with congestive heart failure (HF).

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The dramatic regression noted in the postpartum period in this case suggests the particular significance of hormonal factors in the dynamics of growth and rupture of an AVM. Consistent with the day-night change of P-glycoprotein level, the ex vivo accumulation of digoxin, an Abcb1a P-glycoprotein substrate, into the intestinal segments at the onset of dark phase was significantly lower than it was at the onset of the light phase. Although the beta cell secretary response is mainly controlled by blood glucose levels, gut hormones secreted in response to food intake have an important role in potentiating glucose-stimulated insulin secretion. To investigate the mechanisms involved in processing of the protein encoded by HEV1, three domain-specific antisera were raised against fusion proteins harboring the amino-terminal domain (N domain), carboxyl-terminal domain (C domain), and both domains (NC domain).

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WMHI was associated with low pHi and increased phosphodiester peak. We aimed to investigate whether increased waist-to-hip ratio (WHR), waist circumference (WC), or improper body mass index (BMI) may differently predict short-term outcomes in females and males with first-ever acute ischemic stroke.

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The effector protein AvrP is secreted by the flax rust fungal pathogen (Melampsora lini) and recognized specifically by the flax (Linum usitatissimum) P disease resistance protein, leading to effector-triggered immunity. The VenaTech Convertible filter has a high conversion rate and low 6-month device-related adverse event rate. Unilateral agenesis of the internal carotid artery in CHARGE syndrome. Furthermore, pulmonary edema in acute lung injury is associated with an increase in vascular permeability that may arise from a perturbation of the endothelial cell surface membrane. There is a progressive use of oral drugs versus insulin, and a tendency to prescribe biguanide, sulfonylureas, especially gliclazide and glimepiride.

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A type of running training (continuous endurance and intermittent) before the exhaustive exercise was found to differentiate L-NAME-induced effects in rats. Enzymatic and ionic changes in man associated with physical work. Histologically, the lesion corresponded to a focal area of lipid-laden hepatocytes. Further molecular cluster analysis, such as spoligotyping and DNA finger printing, is still required to determine transmission dynamics and the epidemiological link of the mutated strains. OsNAC6 was also induced by jasmonic acid (JA), a plant hormone that activates defense responses against herbivores and pathogens.

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Plasmonic sensor variation was shown to produce unique data fingerprints for each chemical analyzed, supporting the application of multivariate statistical techniques to annotate unknown samples by chemical similarity. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. The recorded changes in the ultrasound measurements of the blood flow in the eye arteries in premature children comparing to the normal newborns, can be the evidence for the immaturity of the vessel system in the preterm born neonates. Despite significant reductions in antiparkinsonian medications, STN DBS did not reduce excessive daytime sleepiness. MRI is thus a suitable staging procedure for stomach carcinomas.

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Its severity ranges from nearly asymptomatic individuals to perinatal lethality. Plant Vasculature: Selective Membrane-to-Microtubule Tethering Patterns the Xylem Cell Wall. The fetuses of two rats from each group were anatomized on GD18 to extract genital tubercle (GT) to make pathological sections. However, the structures of these large ring lactones have been relatively difficult to elucidate via NMR spectroscopy due to the minute amounts of compounds that are sometimes obtainable from natural sources.

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A bitter pill to swallow: the need for better medications for drug-resistant tuberculosis in children. According to the previous publications regarding GJB2 and GJB4 mutations, the distribution of the mutations is different from other parts of Iran that should be considered in primary health-care programs. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Immortalization of multiple cell types from transgenic mice using a transgene containing the vimentin promoter and a conditional oncogene. Pharmacodynamics, pharmacokinetics in phase I trials, search for kinetic interactions are approached.

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Effective treatment of aggressive fibromatosis with celecoxib guided by genetic testing. It is concluded that NMDA acts at a metabotropic receptor located most likely presynaptically to reticulospinal neurones on terminals of octavomotorius relay cells. The US Food and Drug Administration defines an Rx-to-OTC switch as over-the-counter (OTC) marketing of a drug product that was once a prescription (Rx) drug for the same indication, with the same strength, dose, duration of use, dosage form, population and route of administration.

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These included genes encoding an unusual group 3 late embryogenesis abundant protein, and a number of other stress-related and DNA repair proteins. By limiting the number of sperm theoretically possible per tube to a predetermined maximum and by assuming no chiasma interference, maximum-likelihood estimation can be carried out rapidly using the theory of hidden Markov chains. Histochemical and electrophoretic characteristics of nonspecific esterases of the human myocardium during cardiac muscle diseases The discovery and cloning of CB1 and CB2, the two known G(i/o) protein-coupled cannabinoid receptors, as well as the isolation and characterization of two families of endogenous cannabinergic ligands represented by arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG), have opened new horizons in this newly discovered field of biology.

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The aim of this study was to investigate the roles of Smad2/3 and Smad1/5/8 phosphorylation in transforming growth factor-beta-induced chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells (BMSCs) to assess whether specific targeting of different Smad signaling pathways offers possibilities to prevent terminal differentiation and mineralization of chondrogenically differentiated BMSCs. Movement-induced focal tonic-clonic seizure-like movements after ipsilateral basal ganglia hemorrhage. Polarized neutron reflectivity (PNR) is used to obtain the magnetic depth profile of an antiferromagnetically coupled ferrimagnetic/ferrimagnetic bilayer, Gd40Fe60/Tb12Fe88.

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The presence of BPA- or CFU-mix-stimulating activity in the spleen after infection might be responsible for the development of panmyelosis, which is a characteristic of MPSV-induced myeloproliferative syndrome. Here, the authors show a user-friendly device that couples CO2 electroreduction with carbonylation chemistry for up to gram scale synthesis of pharmaceuticals even under atmospheric CO2. In the course of ontogeny, the homing site for the hematopoietic stem cells (HSC) moves with certain predictability from the yolk sac to the liver/spleen and then to the marrow.

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We report on an experiment to use the natural language processing tools being developed in the SPECIALIST system to accurately identify terminology associated with the coronary arteries as expressed in coronary catheterization reports. We present a 13-years retrospective histological study of 444 thyroidectomies received between 1989 and 2001 at the Morbid Anatomy department of the Lagos University Teaching Hospital, Nigeria. The performance improvement that results from including the evolutionary information in the analysis is illustrated.

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Ileocecal masses in patients with amebic liver abscess: etiology and management. The area of activated HSCs increased significantly in zones 1 and 2, and more prominently in zone 3 of the liver tissues after BMT than normal liver tissues, and was much larger in zone 3 of liver tissues with VOD.

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