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Influence of aglycone modifications on the binding of anthracycline drugs to DNA: the molecular structure of idarubicin and 4-O-demethyl-11-deoxydoxorubicin complexed to d(CGATCG). An X-ray fluorescence imaging microscope with a Wolter-type objective mirror (magnification: 13) has been constructed at beamline 39XU of SPring-8. Complex chromosomal rearrangements (CCRs) are constitutional structural rearrangements that involve three or more chromosomes or that have more than two breakpoints. Oncology clinicians differed in their attitudes toward truth telling of different stages of cancer.

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Descriptions of pathology of chronic bronchitis in the past have been mainly focused on mucous gland hypertrophy, since this was considered the morphologic basis of the disease, but more recent studies have suggested a pathogenetic role for airway inflammation in subjects with chronic bronchitis. Assessment of glutamatergic agents indicated that the mGlu1 receptor antagonist LY456236 (10-30 mg/kg), mGlu5 receptor antagonist MPEP (10-30 mg/kg), mGlu2/3 receptor agonist LY354740 (3-10 mg/kg), mGlu2 receptor potentiator LY566332 (30 and 100 mg/kg), mGlu8 receptor agonist (S)-3,4-dicarboxyphenylglycine (30-60 mg/kg), competitive NMDA receptor antagonist LY235959 (1 mg/kg), AMPA receptor antagonist GYKI-52466 (10-20 mg/kg), and glycine transporter-1 (GlyT-1) inhibitor ALX-5407 (3-10 mg/kg) dose-dependently attenuated stress-induced hyperthermia. Recently, a number of experiments have sought to directly test this principle using coherent light, single photons, and nuclear spin states. Despite this additional regulating input to the muscle spindle, it appears that muscle spindle information from the lengthening muscle is important for the accurate perception of limb movement and/or position.

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In one case, color Doppler sonography failed to detect the aneurysm because of a markedly calcified aneurysmal wall, although power Doppler sonography could visualize the aneurysm. Predictors of Use of Hearing Protection Model and Trans-theoretical Model were tested. An operated case of gestational ovarian choriocarcinoma formed a huge abdominal tumor The genus Brauniellula, which is based upon the secotioid habit and the presence of orthotropic, statismosporic basidia, falls within Chroogomphus in a clade with ballistosporic species. Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system.

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Compared to the three ribosomal defined domains, we report a single common origin for Nucleocytoplasmic Large DNA Viruses (NCLDV), DNA processing genes rooted between Archaea and Eukarya, with a topology congruent with that of the ribosomal tree. More importantly, we discovered an age-related decrease in Btfor expression in both nursing and foraging bumblebees. Analgesia-based sedation techniques are becoming more established in the intensive care unit (ICU) setting. Dilated cardiomyopathy with mitral regurgitation: decreased survival despite a low frequency of left ventricular thrombus.

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Inguinal lymph node metastasis from contralateral testicular origin. Our results show that distinct subsets of human DCs, differently from all other mononuclear hemopoietic cells, specifically do not express CD48.

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The influence of intake level and corn processing on digestibility and ruminal metabolism in steers fed all-concentrate diets. Measuring the agents of natural selection is important because it allows us to understand not only which traits are expected to evolve but also why they will evolve. Pakistan Journal of Medical Sciences: A bibliometric assessment 2001-2010. Rather, the transformants expressing the adhesin determinants were selectively eliminated by the host. Waveguides are used in a number of areas of medical ultrasonics and it is therefore important to be able to model sound propagation in them accurately.

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Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. While infected viable immature DC failed to undergo maturation despite cytokine treatment, both DC populations efficiently presented MVA-produced target antigen. A single administration of ouabain significantly prolonged BoNT/A-induced neuromuscular paralysis. When anti fms (hM-CSF receptor) antibody was added, hCG secretion by cultured human cytotrophoblasts in early pregnancy markedly decreased. The fabrics were dyed with dyes of three different dye chemistry and assessed for its dyeing performance without the addition of salt.

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This unique protein species was generated by biotinylation of spinal cord tissue extracts to detect conformational changes of SOD1 specific to ALS patients. Idiopathic Low Ovarian Reserve Is Associated with More Frequent Positive Thyroid Peroxidase Antibodies.

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The lactose-specific phosphocarrier protein enzyme III of the bacterial phosphoenol-pyruvate-dependent phosphotransferase system of Staphylococcus aureus was modified by site-specific mutagenesis on the corresponding lacF gene in order to replace the histidine residues 78 and 82 of the amino acid sequence with a serine residue. This study presents a cross-sectional analysis of baseline data from a multi-center prospective cohort study. Forty ASA physical status I, II, and III patients presenting for primary total hip replacement.

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Wnt-1 induces morphological transformation of C57MG mammary epithelial cells and accumulation of cytosolic beta-catenin whereas Wnt-5a has no effect. A traditional pathway for developing new health products begins with public research institutes generating new knowledge, and ends with the private sector translating this knowledge into new ventures. Ten days following the PAN injection, urine protein, creatinine, nitric oxide (NO) and malonyldialdehyde (MDA) were measured. The loss of exons correlated strongly with the loss of MLH1 and MSH2 protein expression. We performed qualitative constant comparative analysis of transcript data.

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Even though a multifaceted intervention can improve process of care measures for Whites and African Americans, further studies are needed to improve outcome measures, especially in African Americans. Involve your Clinical Engineering Department in your investigations. Matrix metalloproteinases (MMPs) orchestrate tissue remodeling and play diverse roles during organ development.

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The microvascular dimensions and densities were used to predict the average blood flow velocity within the kidney cortex. These findings suggest that more than one mechanism is involved in NNRTI hypersusceptibility.

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The testes were normal on physical and ultrasound examination, and the retroperitoneum was free of tumor. Danofloxacin (Advocin) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattle. mucosalis was isolated from blood in an immunocompromised patient with symptoms of pneumonia. The frequency of aneuploidy of marker chromosomes was significantly higher in older mice (2 years old) than in younger ones. A lack of these spaces in deciduous dentition may result in disproportionate jaw and tooth sizes.

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Salvage Surgery After Definitive Chemoradiotherapy for Non-small Cell Lung Cancer. In a previous study 12 Washington State hospitals reported evacuations due to hazardous materials incidents. Alcohol craving has many analogies in psychopathology with obsessive-compulsive behavior patterns. The goal of our study is to understand what factors determine an organisms fitness or competitive ability in serial transfer culture. All these features should be taken into account for a more accurate and relevant assessment of the distance.

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In the present work, evacuolated protoplasts were used to show that this response resides only at the plasmalemma. Although spatial neglect is more severe in contralesional than ipsilesional hemispace in the period immediately following a stroke, over time patients with RHD may develop ipsilesional neglect that is more severe in ipsilesional than contralesional space. Unicortical screw fixation at occipital protuberance offers acceptable pullout strength without the potential complications of bicortical screws or wire fixation. The low concentration of ASU014 and sub-MIC concentration of oxacillin necessary for activity suggest that this molecule is a candidate for future medicinal chemistry optimization. The concept of the acceptable daily intake: an historical review.

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Two hours after iliac crest bone harvesting, the patient experienced syncope and severe hypotension. Common AKR1B1 polymorphisms are unlikely to be major determinants of diabetic nephropathy in this population. Studies that compare recent life events of anxiety disorder subjects and controls have equivocal results. The incidence rate of carriership of hepatitis B (HBV) and hepatitis C viruses (HCV) is many times greater than morbidity rates in acute and chronic forms of the disease. Production of purple pigment by a mutant of Serratia marcescens.

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Endothelium-dependent vasodilation is abnormal in experimental models of diabetes mellitus. Synthesis of substituted pyridine derivatives via the ruthenium-catalyzed cycloisomerization of 3-azadienynes. This condition caused the patient in the current case report to have a lack of confidence when speaking. A summary of the latest understanding of the mechanisms of action of corticosteroids and the most recent observations in the clinical and biologic responses to corticosteroids in severe sepsis and septic shock is presented. A literature search was conducted on MEDLINE and Current Contents, from January 1996 to March 1998, using the search strategy recommended by the Cochrane Collaboration for the identification of randomized controlled trials (RCT).

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As both antibiotics target the large mtrRNA of the mitoribosome, we focused our analysis on mitochondrial translation. Editorial: Lupus, the Chameleon: Many Disguises Difficult to Capture. DFT calculations show that H(2)O(2) adsorption on Pt(110) results in the dissociation of O-O bond and the formation of Pt-OH bond. Cross-linking of the aldolase subunit by an -S-S-bridge between Cys72 and Cys338 inactivates the enzyme, abolishes binding of active-site ligands, and induces a conformational change in the enzyme that can be detected far away (at Cys239 and Cys289) from the site of perturbation. Bone marker levels reflect ongoing skeletal metabolism and can provide important insights into bone health and response to bisphosphonate therapy in patients with prostate cancer.

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Multiple compound composite odontomas of maxilla and mandible: report of case. In Western blot analyses of CAF, an immunoreactive bFGF-like protein of about 17 x 10(3) Mr is recognized by a monospecific anti-bFGF antiserum. Developmental and functional outcomes in children with global developmental delay or developmental language impairment. Double filtration plasmapheresis (DFPP) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro.

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Reconstruction of the knee joint with an appropriate prosthetic component that accomplishes the alleviation of pain and the restoration of joint function represents the goal of primary and revision TKA. No cross-reactivity between C6 and D5 and the neurophysins was apparent, nor did anti-neurophysin sera recognize the bands identified by C6 and D5. In recent years, the use of mammalian target of rapamycin inhibitors has gained traction in their use as alternative or adjunct immunosuppressants in the post-liver transplantation (LT) setting. Vitamin A-deficient rats were produced as a model of severe dry eyes, and the expression of the mRNA and the enzyme activity of TG1 were examined in the corneas.

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Multiple organ malrotation syndrome with duodenal atresia: a case report. Awkward posture and prolonged working hours are responsible for developing back pain among ophthalmologists. Electropherotyping was performed for the rotavirus-positive samples.

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Passive avoidance training and recall are associated with increased glutamate levels in the intermediate medial hyperstriatum ventrale of the day-old chick. Regulation of dopamine receptors by bupropion: comparison with antidepressants and CNS stimulants. Although a strong relationship was established between the non-fatal cases and administration of Sonovue, a causal relationship between the fatal cases and the use of Sonovue is debatable. Dependent measures included cardiovascular effects of methamphetamine, methamphetamine and amphetamine pharmacokinetics, and peak and trough plasma concentrations of bupropion and its metabolites. Relativistic many-body calculation of the electric dipole moment of atomic rubidium due to parity and time-reversal violation.

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Although the precise mechanism of the effect of cyclosporine on liver ischemia still remains unknown, these observations may be of use in liver transplantation. In conclusion, vertical transmission of HIV through breastfeeding is possible and perhaps should be more closely evaluated. In the coverage below monolayer the physisorbed and chemisorbed species coexist at 35 K in the gauche and slightly distorted trans form, respectively. The close resemblance of JCV(CY) induced tumor in transgenic mice to the human medulloblastoma/primitive neuroectodermal tumor (PNETs) in location, histologic appearance, and expression of marker proteins strongly suggests the utility of this novel animal model for the study of human brain tumors.

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Venetoclax (ABT-199) is a Bcl-2-specific BH3-mimetic that has shown significant promise in certain subtypes of CLL as well as in several other hematologic malignancies. Mind-body techniques, such as biofeedback and breathing-based stress reduction, have shown some promise in the treatment of PTSD symptoms. The MCNP results are presented and compared with results of an analytical approach and with experimental data collected after installation. Given the flexibility of manipulating functional groups on the nanoprobes, their low cost, robustness, and simplicity of the assay, our approach shows promise for targeted proteome profiling in clinical settings. Linkage between cellular adherence and biofilm formation in Escherichia coli O157:H7 EDL933.

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Statistical interpretation of chromatic indicators in correlation to phytochemical profile of a sulfur dioxide-free mulberry (Morus nigra) wine submitted to non-thermal maturation processes. However, sustained-release microsphere formulation would fail to accomplish the task of long-lasting drug release unless microspheres remained for a prolonged period at the site of action. We report a 28 year old female consulting for infertility and a 26-year-old woman consulting for severe dysmenorrhea. The features of this vein can be affected by the large distention pressures it is submitted to during its preparation and insertion into the arterial system.

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In one series, 75 of 85 patients had positive identification of a suspected liver tumour with laparoscopic ultrasound examination. This analysis identified the need for additional scale-up factors to account for non-uniform filter area usage in large-scale filter housings.

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Ninety-one children, aged 13 to 14 years, from junior high schools in Japan. We analyzed these data by use of a compartmental model in which the vascular bed is represented by three parallel compliances separated by two series resistances, and each of the three compliances and the two resistances can be identified.

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Proteins that exhibited altered expression in the present study are potential targets for vector control strategies and development of transmission blocking vaccines in the fight against malaria. Hematological changes, bone marrow toxicity, plasma and tissue distribution study of free, uncoated plain liposomal and galactosylated liposomal encapsulated azidothymidine (AZT) were determined following a bolus intravenous injection in Sprague-Dawley rats. Post-mortem analyses of coronary arteries have indicated that obesity (associated with a high accumulation of abdominal fat measured at autopsy) was predictive of earlier and greater extent of large vessels atherosclerosis as well as increase of coronary fatty streaks. The purpose of this study was to assay the concentration of metronidazole in gingival fluid, to correlate clinical and microbiologic parameters of periodontal disease to each other and to the gingival fluid concentration of the drug.

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Fears of complications related to mesh implantation have proved to be without foundation. This review focuses on the role of the central melanocortin system in body weight regulation, and specifically on the anticatabolic properties of antagonists of the melanocortin-4 receptor. Most adolescents were included in the diagnosis of Eating Disorder Not Otherwise Specified, according with other studies in this age. We said at the outset that such evidence could only suggest testable hypotheses and that recommendations must ultimately rest on more conventional epidemiological, clinical, and laboratory studies.

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In summary, the insulinomimetic effects of W and Mo appear to resemble qualitatively that of vanadate in all respects. Gas chromatographic and mass spectrometric analyses of derivatized culture medium extracts were used to identify the products of flavonoid metabolism by rhizobia. On the morphogenesis of the regenerating mesencephalon in larvae of Xenopus laevis

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Complement component C4 deficiencies and gene alterations in patients with systemic lupus erythematosus. Both the Hox 7-like genes and Hox 8-like genes are present throughout the vertebrates.

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To provide appropriate management, clinicians must have a clear understanding of the etiology and pathophysiology of gastroschisis. Clinical conference on management dilemmas: progressive pneumonia in a patient receiving long-term steroid therapy.

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Negative bias in cognition is closely associated with susceptibility to recurrent episodes of depression. Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole. Despite their importance in professional antigen presentation and their ubiquitous presence, dendritic cells (DCs) are usually found in such trace amounts in tissues that their isolation with high purity is a difficult task. Psoriatic Arthritis (PsA) is a chronic inflammatory disease of the joints. Atomically thin hexagonal boron nitride (h-BN) layers on metallic supports represent a promising platform for the selective adsorption of atoms, clusters, and molecular nanostructures.