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Laser-microtextured surfaces promote soft tissue attachment and provide a tight seal around implants. The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse. The physical and mechanical properties of TBF, a bulk fill resin composite, were similar or superior to those of ED, a conventional composite, with the exception of FS measurements. Our results showed that it is valid, reliable and reproducible and has the potential to be used in clinical practice. Thus, our data demonstrated that VPA and HU synergistically suppressed tumor cells via disturbing RPA2-p-mediated DNA repair pathway, which provides a new way for combining chemotherapeutic drugs to sensitize breast cancer cells.

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Perioperative nursing: moral and ethical issues in high--technology practice. The aim of this study was to clarify the mechanism that gives rise to inactivation of p16(INK4) in hepatocellular carcinoma. Consumption of a high quantity and wide variety of vegetables is currently recommended for health. We tested if TTX can be induced by exposing populations of adult and larval California newts (Taricha torosa) to sustained stressful conditions while longitudinally quantifying TTX concentrations. Results indicate that, either sampling performance or sampling efficiency, MCMC method both has its special advantages in producing posterior distribution.

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The authors report about the cases of two infants less than 5 weeks old, who presented with congenital subglottic stenosis and in whom a cricoid split produced good results. By contrast, the cytotoxicity of Pseudomonas exotoxin A (PE) is reduced by expressing lysozyme-KDEL, which causes a redistribution of the KDEL receptor from the Golgi complex to the ER, and cells are sensitised to this toxin when they express additional KDEL receptors. Breast cancer survivorship: the role of perceived discrimination and sexual orientation. Similarities in the genome organization of tobacco rattle virus and pea early-browning virus isolates that are transmitted by the same vector nematode. An important association between non-typhoidal salmonella bacteremia and human immunodeficiency virus (HIV) infection has been demonstrated in both industrialized and developing countries.

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Further studies are warranted to replicate study findings and determine host and infection characteristics associated with large PSA increases. Genetic vaccination against Coccidioides immitis: comparison of vaccine efficacy of recombinant antigen 2 and antigen 2 cDNA. Dynamic SERS nanosensor for neurotransmitter sensing near neurons. To determine prevalence and predictors of electrical storm recurrences (ES-Rs) in patients with implantable cardioverter-defibrillators (ICDs) as electrical storms (ESs) represent serious clinical events carrying a high risk of mortality. Performance of this algorithm was evaluated on dual channel endocardial electrograms recorded in the cardiac electrophysiology laboratory.

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The small increase in serum phosphate concentration may result in reduced bone density and increased risk of bone fractures, mainly seen with canagliflozin, but recent meta-analyses did not show increased risk of bone fractures with SGLT2 inhibitors. Historically, cytotoxicity has been investigated with radioactive methods, which are cumbersome, expensive and potentially hazardous. Recombinant pH1N1 viruses were generated by reverse genetics, expressing either the wild-type or any of 9 mutant neuraminidase (NA) proteins (N2 numbering: E119G, E119V, D198G, I222V, H274Y, N294S, S334N, I222V-H274Y, and H274Y-S334N). The assessment of proliferation, differentiation and viability through trypan blue, methylthiazol tetrazolium, and von Kossa and alizarin red assays, respectively, were held within fixed intervals: 7, 14, 21 and 28 days.

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A prospective comparative study between antepartum vibratory acoustic stimulation test (VAS-T) and nonstress test (NST) was done in 103 pregnant women. Here we show that the nature and the selection of onychophoran neural precursors are distinct from euarthropods. Drug treatment during the MT stage phase-shifted the schizogonic cycle by 18 hours.

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In 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Collaborative partnerships between nursing faculties and health service providers are the cornerstone of successful clinical experience for nursing students. Esterase activity assays of sliced gels from isoelectric focusing (IEF) of serum from mice treated with CCl4 indicated the presence of at least three additional esterase peaks when compared with serum of control mice. Classical galactosaemia in Chinese: A case report and review of disease incidence.

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Isoproterenol induced a transient (12 h) hepatic and a biphasic (12 and 36 h) renal and cardiac increase. The apoptosis of HCC cells only partially depended on the upregulation of DR5 and the status of p53. These findings suggested that macrophages aid in protection against infection when damage to the bactericidal capacity of neutrophils results in insufficient elimination of microorganisms. Significant differences in tumor response ratings were detected comparing UFTR and computer-aided standardized evaluation based on RECIST 1.1.

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In this study, children who received dental restorative treatment with amalgam did not, on average, have statistically significant differences in neurobehavioral assessments or in nerve conduction velocity when compared with children who received resin composite materials without amalgam. We examined whether cryopreserved mouse eight-cell embryos could be thawed, biopsied, refrozen, thawed, and grown in vitro and in vivo in two sets of experiments. In contrast, agents to stimulate the immune system--like IFN-gamma or G-SCF--may prove beneficial.

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Mutation screenings were performed on coding exons of both genes with either denaturing gradient gel electrophoresis or denaturing high performance liquid chromatography, or with both techniques. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Cepharanthin depressed aniline hydroxylase and aminopyrine demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice.

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Nucleic acid from an adeno-associated virus: chemical and physical studies. Diastereoselective spiroketalization: stereocontrol using an iron(0) tricarbonyl diene complex.

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Initial trials evaluating exposure-based interventions for eating disorders (EDs) in the 1980s demonstrated mixed results. DNA fragmentation was observed in hepatocytes as well as infiltrating mononuclear cells. To evaluate usage patterns for methotrexate (MTX) and/or glucocorticoids in rheumatoid arthritis (RA) patients receiving biological disease-modifying antirheumatic drugs (bDMARDs) in daily practice. Furthermore we propose that this method to obtain the IC:MC fraction can be applied for the study of other microorganisms or cells with high enzymatic content. This pattern is subsequently maintained after germ band extension by interaction among the segment-polarity genes themselves.

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Reduction of endogenous free beta-catenin levels by overexpression of C-cadherin leads to complete inhibition of signaling by the membrane-tethered repeat region. From their responses, 45 questions were developed, edited for clarity, and piloted. Editorial: The 2016 Pediatric Neurology Trainee Publication Award. To determine the role of HSF-1 in regulating miRNA expression, we have performed high-throughput small RNA-sequencing in C.

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Adenosine stress myocardial perfusion tomographic imaging is an useful non-interventional method for detecting coronary artery disease. In 13 patients who remained seizure-free during the two month-period of observation, IEA was unchanged or decreased.

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The lines and methods established in this work may prove useful in future studies of the mechanism and frequency of gene exchange in Leishmania. The overall results demonstrate that 6-MP is actively metabolized in rats and that its biotransformation can be modulated by agents acting on enzymes of the purine metabolism, resulting in significant changes in erythrocyte and tissue levels of 6-MPN and 6-TGN. Patients were included after completing an agreement form regarding the treatment plan (emphasizing therapeutic exercise, health education and as little medication as possible) in the first interview. The relationship of mentoring to job satisfaction of critical care nurses.

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Association was sought between the degree of allergic rhinitis control (RCAT) as independent variable and sleep quality as dependent variable using linear regression. Pellet size affects mycelial ergosterol content in aquatic hyphomycetes.

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Among 549 patients, 15 had 2 or more ascendant first- and second-degree relatives who committed suicide. We present the case of an endograft repair of a blunt, traumatic inferior vena cava injury in a patient deemed at high risk for surgical repair. Patient factors, limb characteristics, procedure type, and intraoperative variables were analyzed by the level of amputation. The main outcome measures were time interval between the injury and presentation, presenting visual acuity, grade of injury, management (medical therapy or surgical intervention), and final visual outcome at the last follow-up.

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Through its C-terminus, APC binds to post-synaptic density discs large zonula occludens domain-containing proteins, such as discs large (DLG) and post-synaptic density (PSD)-95, and may play important roles in epithelial morphogenesis, brain development and neuronal functions. The present study was aimed to investigate the expression profile of hABH2 in gastric cancer and the effect of hABH2 on cancer cell growth. The second link is platelets, which stored in and after activation release proteins with procoagulant and proinflammatory properties. Fast computation of supertrees for compatible phylogenies with nested taxa.

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Strongyloides stercoralis: histopathological findings of duodenal mucosa (1999-2005) Bone collagen, mineral and trace element composition, histomorphometry and urinary hydroxyproline excretion in chronically-treated alcohol-fed rats. Whole cell perforated patch-clamp recordings and single-cell RT-PCR analysis were performed on the primary afferent neurons retrogradely labeled from the esophagus in the guinea pig. Current therapeutic strategy is resection through an extradural subtemporal craniotomy with removal of the petrous apex and clivus. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin.

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Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro. Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, a disease confined to Latin America and of marked importance in the endemic areas due to its frequency and severity.

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sampsonii extract depended on levels of RXRalpha, as it failed to inhibit the growth of CV-1 cells lacking detectable RXRalpha, whereas transfection of RXRalpha into CV-1 cells restored its apoptotic response to H. Primary prophylaxis is recommended in patients with large and high risk gastric varices to reduce the risk of first bleeding and mortality. The treatment applied in this study could improve the prognosis of patients after acute phase of HUS evidently by using the steroid and immuno suppressor according to clinical classification and pathological findings. In contrast, there was no consistency in seeing the fastest or slowest surface in front. As a host response to control disease, many macrophages become apoptotic a few days after MAC infection.

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Biological and medical research offer rigorous techniques and scientific methodologies to explore how features of the built environment influence human health, performance, and well-being. The second patient is a 34-year-old man with a past medical history significant only for life-long migraine headaches successfully treated for the past six years with zolmitriptan.

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We find that many of the major structural transitions occur cooperatively, at a point coincident with promoter release. Experts were canvassed regarding the impact of new technology on OMPs. The cleavage of the PGG grafts from the HA backbone is quantified and polymer-from-polymer release kinetics are determined. Up to 24 months, the mesencephalic trigeminal neurons progressively accumulate lipofuscins, while filamentous inclusions start to appear around 24 months of age.

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One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. Increasingly, patients are expected to influence decisions previously reserved for regulatory agencies, pharmaceutical companies, and healthcare professionals.

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Clinico-pathological study on the effect of leucomycin and its preparations on exposed pulp tissue Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from thalictrum przewalskii Proteolytic activity of the barotolerant bacterium, bacterium candicans var.

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Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis. Pressure from husbands and in-laws compels women for consulting multiple providers. Vertebral artery patency on 3D CEMRA in cases in which the vessel is absent on the TOF localizer in association with ipsilateral subclavian artery stenosis indicates reversal of flow in the vertebral artery and confirms the subclavian steal phenomenon. The results highlight several areas where health care managers, whether from correctional or noncorrectional environments, could implement policy and procedure changes to further engage and retain the clinical workforce. The cyst raised progressively in dimension, the actual size being of 6.5 cm.

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However, conversion to GA is appropriate when unexpected intraoperative findings are encountered or for patient comfort. The exact degree of renal pelvic dilatation that requires full postnatal investigation is still not entirely resolved.

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This association study provides no evidence that length variations of the second polyglutamine array in the N-terminus of the KCNN3 channel exert an effect in the pathogenesis of migraine. Comment on Canine scent detection for the diagnosis of lung cancer in a screening-like situation. In the current study, we investigated the relationship between pleuromutilins, including valnemulin, tiamulin, and retapamulin, and 13 other antibiotics representing different mechanisms of action, against methicillin-susceptible and -resistant S. Micelles of hydrated chlorophyll a (P740), bacteriochlorophyll a (P865), bacteriochlorophyll c (P750), and pheophytin a prepared in organic media have been studied by small-angle neutron scattering to determine their shape, size, and mass per unit length. No similar nests of marker-positive cells were detected in any area of normal liver outside the HNs.

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Patients with significant medical comorbidities such as chronic kidney disease (CKD) traditionally have been excluded from hematopoietic stem cell transplantation (HSCT) because of unacceptably high transplant-related morbidity and mortality, an exclusion that can have enormous consequences for patients with CKD from myeloma in particular. Abdominal deflation did not reverse the pulmonary function impairment associated with pneumoperitoneum.

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A comparison of the measured signal in each voxel with the physical model yields quantitative parameter maps. The role of Ach in the central nerve system on pain modulation and analgesia GWAS and GS address different aspects of quantitative traits, but, as statistical models, they are quite similar in their description of the genetic mechanisms that underlie quantitative traits. We found successful threat conditioning as threatCS was rated as more aversive (negative, arousing, anxiogenic and associated with US) than the other cues, and it elicited startle potentiation as well asa larger skin conductance response (SCR). The hypothermia produced by exposure to 5 Gy of 56Fe particles is mediated by histamine and can be attenuated by treatment with the antihistamines mepyramine and cimetidine.

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This is the first study to demonstrate developmental plasticity of Hb subunit expression in a notostracan, Triops longicaudatus, reared under conditions of varying oxygen availability. H2 also regulates gene expression involved in intracellular signaling and metabolic pathways. These patients were divided into four groups and followed by intraperitoneal administration of saline,methylene blue,aprotinin,combined methylene blue and aprotinin respectively during the second operation, then adhesion formation was quantitatively graded. The seven-spanning transmembrane G-protein coupled receptor CXCR4, which specifically binds to the chemokine CXCL12, is expressed on many cell types, including various types of tumour cells. A combination of ovalbumin and endotoxin also increased the response to adenosine but the effects were at best additive.

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Voltage-time course and the effect of acetylcholine on atrial and nodal cells of the rabbit heart. An activated clotting time was used to confirm heparin neutralization.

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Ten subjects participated in the method validation, performing free rotations (flexion/extension, lateral bending and axial rotation) from standing to the maximum excursion and back. They had abilities to keep the wound in moist environment and meanwhile prevent the excess exudates accumulation. Surgical treatment for lumbar hyperlordosis after resection of a spinal lipoma associated with spina bifida: A case report. At the present, fetal survival cannot be a measure of the success of a surgical procedure because so many other factors play a role in outcome, such as the quality of obstetrical and neonatal care.

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Both techniques provide a high sensitivity (in the nanomolar range), which is of particular importance for molecular imaging. Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc. While these effects could have been due to different response rates and histories of the two groups being compared, a subsequent study found differential effects using a within-subjects design, in which rates of responding were well equated. Neurological adverse events with spinal cord ischemia (SCI) remain one of the most feared complications in patients undergoing thoracic endovascular aortic repair (TEVAR). Oxidized low density lipoprotein (oxLDL) is believed to play a central role in atherogenesis.

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When the effects of mutations of the Ras effector region residues were examined for associations with various effectors, Ce-AF-6 was found to possess a distinct and the most rigorous requirement for the effector region residues. High dietary sodium enhances gustatory nerve activity and behavioral responses to NaCl. Functional brain imaging in the clinical assessment of consciousness.

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There was a systematic bias between the TIP and radiographically determined assessments. The effect of urea loading on volume and concentration of urine in rabbits. Tissue adhesive glue is faster and probably less painful than suturing. Seventy six non-alcoholic, non-smoking hepatitis B virus (HBV) negative men with normal body mass index, who denied blood product transfusion or use of medication, were studied (30 healthy volunteers (control group) and 46 patients with the hepatointestinal form of schistosomiasis). Problem of signal transmission via quantum correlations and Einstein incompleteness in quantum mechanics.

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In vivo interobserver and interscan studies on low-dose data from eight clinical metastasis patients revealed that clinically significant volume change can be detected reliably and with negligible computation time by the presented methods. Effect of backpack weight on postural angles in pre-adolescent children: can it predict long term morbidity?

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Ectopic expression of LT-resistant MKK2 and MKK4 variants partially restored Erk1/2 and JNK1/2 signaling in LT-exposed cells, enabling the cells to maintain relatively normal c-Jun protein levels and cell proliferation. Influenza A virus (IAV) infection is often followed by secondary bacterial lung infection, which is a major reason for severe, often fatal pneumonia. Potassium ion transport by valinomycin across a Hg-supported lipid bilayer. In a stably transfected NIH 3T3 cell-line, brief exposure to 1 muM clozapine caused a 2.5-fold increase in intracellular 5-HT2A-like immunoreactivity, as measured by confocal microscopy. However, typical processes for the formation of polymer vesicles lead to ensembles of structures with a broad size distribution (from nanometer to micrometer scale) which result in a limitation for efficient cellular uptake.